Conclusive Evidence for Human Transneuronal Retrograde Degeneration in the Visual System
نویسندگان
چکیده
Damage to axonal fibers in both central and peripheral nervous system leads to degeneration. The degeneration can be anterograde (Wallerian) in which injury to the cell body or proximal regions of the axon leads to degeneration in the axon distal to the damage. Retrograde degeneration is death of the cell body following axonal injury and can be seen throughout the Central Nervous System (CNS) in sensory systems including visual [1], auditory [2], olfactory [3], somatosensory [4] and pain [5] as well as motor systems [6].
منابع مشابه
Direct demonstration of transsynaptic degeneration in the human visual system: a comparison of retrograde and anterograde changes.
Transneuronal degeneration of retinal ganglion cells was directly demonstrated in a patient who had unilateral removal of the striate cortex forty years prior to necropsy. For comparison, another case is presented showing anterograde transneuronal atrophy forty years after enucleation of one eye.
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